Project: “Understanding cellular renewal and aging in kidney epithelium”
Primary Mentor: Steve Artandi, MD, PhD, Associate Professor of Medicine (Hematology)
Secondary Mentor: Glenn Chertow, MD, Professor of Medicine (Nephrology)
After completing PhD training in the National Institute of Agricultural Research in France, Marina Shkreli joined the Stanford School of Medicine as a postdoctoral scholar in 2007. Her research is on progressive impairment of kidney function as a hallmark of aging in humans and in rodents. Her work at Stanford led her to hypothesize that podocytes in the kidney possess a previously under-appreciated capacity for renewal during life and that this is important in maintaining a functional filtration barrier during adulthood. The goal of her current work is to determine if and how podocytes renew in adult mice, to identify the pathways involved in this process, and to understand how podocyte renewal is impaired in aging.