Antidepressant medicines tend to be faster in treating an episode of depression, says Douglas Noordsy, a psychiatrist with the Stanford Lifestyle Medicine Program. “But physical exercise has more durable effects than an antidepressant does,” he says.

For some people, medication gives them a benefit in the beginning, but then it fades over time, Noordsy says. “Whereas a lifestyle change can have a more permanent and lasting effect.” Noordsy and his colleagues use a range of evidence-based recommendations and tools, from medicines to therapy to behavioral approaches including fitness, nutrition, sleep and stress management, to help empower patients.