The focus of Katrin Chua's research is understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.

Contact Info:

kfchua @ stanford.edu

Phone: (650) 493-5000

Stanford University Medical Center
300 Pasteur Drive
Grant Bldg., Rm. S-025
Stanford, California 94305

Personal URL: target=_blank>http://med.stanford.edu/profiles/Katrin_Chua/